ExplorEnz: EC 4.1.1.50

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4.1.1.50

Accepted name:

adenosylmethionine decarboxylase

Reaction:

S-adenosyl-L-methionine = S-adenosyl 3-(methylsulfanyl)propylamine + CO₂

For diagram of spermidine biosynthesis, click here and for diagram of spermine biosynthesis, click here

Glossary:

S-adenosyl 3-(methylsulfanyl)propylamine = (3-aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium

Other name(s):

S-adenosylmethionine decarboxylase; S-adenosyl-L-methionine decarboxylase; S-adenosyl-L-methionine carboxy-lyase; S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming]

Systematic name:

S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylsulfanyl)propylamine-forming]

Comments:

The Escherichia coli enzyme contains a pyruvoyl group.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9036-20-8

References:

1.	Anton, D.L. and Kutny, R. Escherichia coli S-adenosylmethionine decarboxylase. Subunit structure, reductive amination, and NH₂-terminal sequences. J. Biol. Chem. 262 (1987) 2817–2822. [PMID: 3546296]
2.	Tabor, C.W. Adenosylmethionine decarboxylase. Methods Enzymol. 5 (1962) 756–760. [DOI]

[EC 4.1.1.50 created 1972]