| EC |
4.1.1.15 |
| Accepted name: |
glutamate decarboxylase |
| Reaction: |
L-glutamate = 4-aminobutanoate + CO2 |
| Glossary: |
4-aminobutanoate = γ-aminobutyrate = GABA
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| Other name(s): |
L-glutamic acid decarboxylase; L-glutamic decarboxylase; cysteic acid decarboxylase; L-glutamate α-decarboxylase; aspartate 1-decarboxylase; aspartic α-decarboxylase; L-aspartate-α-decarboxylase; γ-glutamate decarboxylase; L-glutamate 1-carboxy-lyase |
| Systematic name: |
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) |
| Comments: |
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9024-58-2 |
| References: |
| 1. |
Ambe, L. and Sohonie, K. Purification and properties of glutamate decarboxylase from the field bean (Dolichos lablab). Enzymologia 26 (1963) 98–107. [PMID: 14081858] |
| 2. |
Nakano, Y. and Kitaoka, S. L-Aspartate α-decarboxylase in a cell-free system from Escherichia coli. J. Biochem. (Tokyo) 70 (1971) 327. [PMID: 4937550] |
| 3. |
Roberts, E. and Frankel, S. Further studies of glutamic acid decarboxylase in brain. J. Biol. Chem. 190 (1951) 505–512. [PMID: 14841200] |
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| [EC 4.1.1.15 created 1961] |
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