The Enzyme Database

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Accepted name: pyruvate decarboxylase
Reaction: a 2-oxo carboxylate = an aldehyde + CO2
Glossary: thiamine diphosphate = 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium
Other name(s): α-carboxylase (ambiguous); pyruvic decarboxylase; α-ketoacid carboxylase; 2-oxo-acid carboxy-lyase
Systematic name: 2-oxo-acid carboxy-lyase (aldehyde-forming)
Comments: A thiamine-diphosphate protein. Also catalyses acyloin formation.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9001-04-1
1.  Singer, T.P. and Pensky, J. Isolation and properties of the α-carboxylase of wheat germ. J. Biol. Chem. 196 (1952) 375–388. [PMID: 12980978]
[EC created 1961]

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