EC |
3.8.1.7 |
Accepted name: |
4-chlorobenzoyl-CoA dehalogenase |
Reaction: |
4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride |
Systematic name: |
4-chlorobenzoyl CoA chlorohydrolase |
Comments: |
Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141583-18-8 |
References: |
1. |
Chang, K.H., Liang, P.H., Beck, W., Scholten, J.D., Dunaway-Mariano, D. Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3. Biochemistry 31 (1992) 5605–5610. [PMID: 1610806] |
2. |
Crooks, G.P., Copley, S.D. Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1. Biochemistry, 33 (1994) 11645–11649. [PMID: 7918379] |
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[EC 3.8.1.7 created 1999] |
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