| EC |
3.8.1.6 |
| Accepted name: |
4-chlorobenzoate dehalogenase |
| Reaction: |
4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride |
| Other name(s): |
halobenzoate dehalogenase |
| Systematic name: |
4-chlorobenzoate chlorohydrolase |
| Comments: |
Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 6.2.1.33 (4-chlorobenzoate—CoA ligase), EC 3.8.1.7 (4-chlorobenzoyl-CoA dehalogenase) and EC 3.1.2.23 (4-hydroxybenzoyl-CoA thioesterase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 94047-11-7 |
| References: |
| 1. |
Müller, R., Thiele, J., Klages, U. and Lingens, F. Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from Pseudomonas spec. CBS 3. Biochem. Biophys. Res. Commun. 124 (1984) 178–182. [DOI] [PMID: 6497878] |
| 2. |
Heppel, L.A. and Porterfield, V.T. Enzymatic dehalogenation of certain brominated and chlorinated compounds. J. Biol. Chem. 176 (1948) 763–769. [PMID: 18889931] |
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| [EC 3.8.1.6 created 1989, modified 1999] |
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