EC |
3.7.1.24 |
Accepted name: |
2,4-diacetylphloroglucinol hydrolase |
Reaction: |
2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate |
Glossary: |
phloroglucinol = benzene-1,3,5-triol
2,4-diacetylphloroglucinol = 1,1′-(2,4,6-trihydroxybenzene-1,3-diyl)diethan-1-one |
Other name(s): |
PhlG |
Systematic name: |
2,4-diacetylphloroglucinol acetylhydrolase |
Comments: |
Requires Zn2+. Isolated from the bacteria Pseudomonas fluorescens, Pseudomonas sp. YGJ3 and Mycobacterium abscessus 103. It reduces the antibiotic activity of 2,4-diacetylphloroglucinol. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Bottiglieri, M. and Keel, C. Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0. Appl. Environ. Microbiol. 72 (2006) 418–427. [PMID: 16391073] |
2. |
He, Y.X., Huang, L., Xue, Y., Fei, X., Teng, Y.B., Rubin-Pitel, S.B., Zhao, H. and Zhou, C.Z. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J. Biol. Chem. 285 (2010) 4603–4611. [PMID: 20018877] |
3. |
Saitou, H., Watanabe, M. and Maruyama, K. Molecular and catalytic properties of 2,4-diacetylphloroglucinol hydrolase (PhlG) from Pseudomonas sp. YGJ3. Biosci. Biotechnol. Biochem. 76 (2012) 1239–1241. [PMID: 22790955] |
4. |
Zhang, Z., Jiang, Y.L., Wu, Y. and He, Y.X. Crystallization and preliminary X-ray diffraction analysis of a putative carbon-carbon bond hydrolase from Mycobacterium abscessus 103. Acta Crystallogr. F Struct. Biol. Commun. 71 (2015) 239–242. [PMID: 25664803] |
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[EC 3.7.1.24 created 2019] |
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