ExplorEnz: EC 3.7.1.21

Your query returned 1 entry. Printable version

3.7.1.21

Accepted name:

6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase

Reaction:

6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H₂O = 3-hydroxypimeloyl-CoA (overall reaction)
(1a) 6-oxocyclohex-1-ene-1-carbonyl-CoA + H₂O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA
(1b) 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H₂O = 3-hydroxypimeloyl-CoA

For diagram of Benzoyl-CoA catabolism, click here

Glossary:

3-hydroxypimeloyl-CoA = 3-hydroxy-6-carboxyhexanoyl-CoA

Other name(s):

6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (decyclizing)

Systematic name:

6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (ring-opening)

Comments:

The enzyme, which participates in the anaerobic benzoyl-CoA degradation pathway in certain organisms, catalyses the addition of one molecule of water to the double bound of 6-oxocyclohex-1-ene-1-carbonyl-CoA followed by the hydrolytic C-C cleavage of the alicyclic ring.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Laempe, D., Jahn, M. and Fuchs, G. 6-Hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase and 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, enzymes of the benzoyl-CoA pathway of anaerobic aromatic metabolism in the denitrifying bacterium Thauera aromatica. Eur. J. Biochem. 263 (1999) 420–429. [DOI] [PMID: 10406950]
2.	Kuntze, K., Shinoda, Y., Moutakki, H., McInerney, M.J., Vogt, C., Richnow, H.H. and Boll, M. 6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes. Environ. Microbiol. 10 (2008) 1547–1556. [DOI] [PMID: 18312395]

[EC 3.7.1.21 created 2014]