The Enzyme Database

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Accepted name: fumarylacetoacetase
Reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate
For diagram of tyrosine catabolism, click here
Other name(s): β-diketonase; fumarylacetoacetate hydrolase
Systematic name: 4-fumarylacetoacetate fumarylhydrolase
Comments: Also acts on other 3,5- and 2,4-dioxo acids.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-59-1
1.  Connors, W.M. and Stotz, E. The purification and properties of a triacetic acid-hydrolyzing enzyme. J. Biol. Chem. 178 (1949) 881–890. [PMID: 18117010]
2.  Edwards, S.W. and Knox, W.E. Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione. J. Biol. Chem. 220 (1956) 79–91. [PMID: 13319328]
3.  Meister, A. and Greenstein, J.P. Enzymatic hydrolysis of 2,4-diketo acids. J. Biol. Chem. 175 (1948) 573–588. [PMID: 18880754]
[EC created 1961]

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