Accepted name: 2,6-dihydroxypseudooxynicotine hydrolase
Reaction: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate
Glossary: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 2,6-dihydroxypseudooxynicotine
Systematic name: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase
Comments: The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.
1.  Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine. J. Biol. Chem. 240 (1965) 3669–3674. [PMID: 5835946]
2.  Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. An α/β-fold C—C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans. J. Bacteriol. 187 (2005) 8516–8519. [PMID: 16321959]
[EC created 2012]

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