ExplorEnz: EC 3.7.1.13

Your query returned 1 entry. Printable version

3.7.1.13

Accepted name:

2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase

Reaction:

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H₂O = anthranilate + (2E)-2-hydroxypenta-2,4-dienoate

Other name(s):

CarC

Systematic name:

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase

Comments:

This enzyme catalyses the third step in the aerobic degradation pathway of carbazole. The effect of the presence of an amino group or hydroxyl group at the 2-position of the substrate is small. The enzyme has no cofactor requirement [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Nojiri, H., Taira, H., Iwata, K., Morii, K., Nam, J.W., Yoshida, T., Habe, H., Nakamura, S., Shimizu, K., Yamane, H. and Omori, T. Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10. Biosci. Biotechnol. Biochem. 67 (2003) 36–45. [DOI] [PMID: 12619671]
2.	Riddle, R.R., Gibbs, P.R., Willson, R.C. and Benedik, M.J. Purification and properties of 2-hydroxy-6-oxo-6-(2′-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole. Protein Expr. Purif. 28 (2003) 182–189. [DOI] [PMID: 12651123]

[EC 3.7.1.13 created 2010]