ExplorEnz: EC 3.6.5.4

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3.6.5.4

Accepted name:

signal-recognition-particle GTPase

Reaction:

GTP + H₂O = GDP + phosphate

Systematic name:

GTP phosphohydrolase (protein-synthesis-assisting)

Comments:

Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Connolly, T. and Gilmore, R. The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide. Cell 57 (1989) 599–610. [DOI] [PMID: 2541918]
2.	Connolly, T., Rapiejko, P.J. and Gilmore, R. Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science 252 (1991) 1171–1173. [DOI] [PMID: 1851576]
3.	Miller, J.D., Wilhelm, H., Gierasch, L., Gilmore, R. and Walter, P. GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Nature 366 (1993) 351–354. [DOI] [PMID: 8247130]
4.	Freymann, D.M., Keenan, R.J., Stroud, R.M. and Walter, P. Structure of the conserved GTPase domain of the signal recognition particle. Nature 385 (1997) 361–364. [DOI] [PMID: 9002524]

[EC 3.6.5.4 created 2000 as EC 3.6.1.49, transferred 2003 to EC 3.6.5.4]