The Enzyme Database

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Accepted name: inosine/xanthosine triphosphatase
Reaction: (1) inosine 5′-triphosphate + H2O = inosine 5′-diphosphate + phosphate
(2) xanthosine 5′-triphosphate + H2O = xanthosine 5′-diphosphate + phosphate
Glossary: inosine 5′-triphosphate = ITP
xanthosine 5′-triphosphate = XTP
Other name(s): yjjX (gene name)
Systematic name: inosine/xanthosine 5′-triphosphate phosphohydrolase
Comments: The enzyme, characterized from the bacterium Escherichia coli, preferentially hydrolyses inosine triphosphate and xanthosine triphosphate, which are formed by oxidative deamination damage. By hydrolysing these damaged nucleotides, the enzyme prevents their incorporation into RNA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Zheng, J., Singh, V.K. and Jia, Z. Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis. Structure 13 (2005) 1511–1520. [PMID: 16216582]
[EC created 2020]

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