ExplorEnz: EC 3.6.1.64

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3.6.1.64

Accepted name:

inosine diphosphate phosphatase

Reaction:

(1) IDP + H₂O = IMP + phosphate
(2) dIDP + H₂O = dIMP + phosphate

Other name(s):

(deoxy)inosine diphosphatase; NUDT16

Systematic name:

inosine diphosphate phosphatase

Comments:

The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Iyama, T., Abolhassani, N., Tsuchimoto, D., Nonaka, M. and Nakabeppu, Y. NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. Nucleic Acids Res. 38 (2010) 4834–4843. [DOI] [PMID: 20385596]

[EC 3.6.1.64 created 2013]