Accepted name: glucosamine-6-phosphate deaminase
Reaction: α-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
Glossary: α-D-glucosamine 6-phosphate = 2-amino-2-deoxy-α-D-glucopyranose 6-phosphate
Other name(s): glucosaminephosphate isomerase (ambiguous); glucosamine-6-phosphate isomerase (ambiguous); phosphoglucosaminisomerase (ambiguous); glucosamine phosphate deaminase; aminodeoxyglucosephosphate isomerase (ambiguous); phosphoglucosamine isomerase (ambiguous); 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
Systematic name: 2-amino-2-deoxy-α-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
Comments: The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
1.  Wolfe, J.B., Britton, B.B., Nakada, H.I. Glucosamine degradation by Escherichia coli. III. Isolation and studies of "phosphoglucosaminisomerase". Arch. Biochem. Biophys. 66 (1957) 333–339. [PMID: 13403679]
2.  Comb, D.G., Roseman, S. Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase. J. Biol. Chem. 232 (1958) 807–827. [PMID: 13549465]
3.  Pattabiraman, T.N., Bachhawat, B.K. Purification of glucosamine 6-phosphate deaminase from human brain. Biochim. Biophys. Acta 54 (1961) 273–283. [PMID: 14484386]
4.  Liu, C., Li, D., Liang, Y.H., Li, L.F. and Su, X.D. Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J. Mol. Biol. 379 (2008) 73–81. [PMID: 18436239]
[EC created 1961 as EC, transferred 2000 to EC]