The Enzyme Database

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Accepted name: nitrilase
Reaction: a nitrile + 2 H2O = a carboxylate + NH3
Other name(s): acetonitrilase; benzonitrilase
Systematic name: nitrile aminohydrolase
Comments: Acts on a wide range of aromatic nitriles including (indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides. cf. EC nitrile hydratase.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9024-90-2
1.  Harper, D.B. Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (rhodochrous group) N.C.I.B. 11216. Biochem. J. 165 (1977) 309–319. [PMID: 21655]
2.  Thimann, K.V. and Mahadevan, S. Nitrilase. I. Occurrence, preparation, and general properties of the enzyme. Arch. Biochem. Biophys. 105 (1964) 133–141. [DOI] [PMID: 14165487]
3.  Pace, H.C. and Brenner, C. The nitrilase superfamily: classification, structure and function. Genome Biol. 2 (2001) 0001.. [PMID: 11380987]
[EC created 1965, modified 1989]

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