| EC |
3.5.3.7 |
| Accepted name: |
guanidinobutyrase |
| Reaction: |
4-guanidinobutanoate + H2O = 4-aminobutanoate + urea |
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For diagram of arginine catabolism, click here |
| Glossary: |
4-aminobutanoate = γ-aminobutyrate = GABA |
| Other name(s): |
γ-guanidobutyrase; 4-guanidinobutyrate amidinobutyrase; γ-guanidinobutyrate amidinohydrolase; G-Base; GBH; guanidinobutyrate ureahydrolase |
| Systematic name: |
4-guanidinobutanoate amidinohydrolase |
| Comments: |
Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9013-69-8 |
| References: |
| 1. |
Mora, J., Tarrab, R., Martuscelli, J. and Soberón, G. Characteristics of arginases from ureotelic and non-ureotelic animals. Biochem. J. 96 (1965) 588–594. [PMID: 5862400] |
| 2. |
Thoai, N.V., Thome-Beau, F. and Olomucki, A. [Induction and specificity of enzymes of the new catabolic arginine pathway] Biochim. Biophys. Acta 115 (1966) 73–80. [DOI] [PMID: 5936244] |
| 3. |
Yorifuji, T., Kato, M., Kobayashi, T., Ozaki, S. and Ueno, S. 4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp ATCC 14676: purification to homogeneity and properties. Agric. Biol. Chem. 44 (1980) 1127–1134. |
| 4. |
Yorifuji, T., Kobayashi, T., Tabuchi, A., Shiritani, Y. and Yonaha, K. Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping. Agric. Biol. Chem. 47 (1983) 2825–2830. |
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| [EC 3.5.3.7 created 1972] |
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