ExplorEnz: EC 3.5.3.25

Your query returned 1 entry. Printable version

3.5.3.25

Accepted name:

N^ω-hydroxy-L-arginine amidinohydrolase

Reaction:

N^ω-hydroxy-L-arginine + H₂O = L-ornithine + hydroxyurea

Other name(s):

dcsB (gene name)

Systematic name:

N^ω-hydroxy-L-arginine amidinohydrolase

Comments:

The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y. and Sugiyama, M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob. Agents Chemother. 54 (2010) 1132–1139. [DOI] [PMID: 20086163]
2.	Kumagai, T., Takagi, K., Koyama, Y., Matoba, Y., Oda, K., Noda, M. and Sugiyama, M. Heme protein and hydroxyarginase necessary for biosynthesis of D-cycloserine. Antimicrob. Agents Chemother. 56 (2012) 3682–3689. [DOI] [PMID: 22547619]

[EC 3.5.3.25 created 2013]