ExplorEnz: EC 3.5.3.24

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3.5.3.24

Accepted name:

N¹-aminopropylagmatine ureohydrolase

Reaction:

N¹-(aminopropyl)agmatine + H₂O = spermidine + urea

For diagram of spermidine biosynthesis, click here

Systematic name:

N¹-(aminopropyl)agmatine amidinohydrolase

Comments:

The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Ohnuma, M., Terui, Y., Tamakoshi, M., Mitome, H., Niitsu, M., Samejima, K., Kawashima, E. and Oshima, T. N¹-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus. J. Biol. Chem. 280 (2005) 30073–30082. [DOI] [PMID: 15983049]
2.	Morimoto, N., Fukuda, W., Nakajima, N., Masuda, T., Terui, Y., Kanai, T., Oshima, T., Imanaka, T. and Fujiwara, S. Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis. J. Bacteriol. 192 (2010) 4991–5001. [DOI] [PMID: 20675472]

[EC 3.5.3.24 created 2013]