| EC |
3.5.2.2 |
| Accepted name: |
dihydropyrimidinase |
| Reaction: |
5,6-dihydrouracil + H2O = 3-ureidopropanoate |
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For diagram of pyrimidine catabolism, click here |
| Other name(s): |
hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase |
| Systematic name: |
5,6-dihydropyrimidine amidohydrolase |
| Comments: |
Also acts on dihydrothymine and hydantoin. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9030-74-4 |
| References: |
| 1. |
Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme. Arch. Biochem. Biophys. 226 (1983) 469–483. [DOI] [PMID: 6639068] |
| 2. |
Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes. J. Biol. Chem. 181 (1949) 449–458. [PMID: 15393763] |
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| [EC 3.5.2.2 created 1961] |
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