The Enzyme Database

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Accepted name: streptothricin hydrolase
Reaction: streptothricin-F + H2O = streptothricin-F acid
Other name(s): sttH (gene name)
Systematic name: streptothricin-F hydrolase
Comments: The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Maruyama, C. and Hamano, Y. The biological function of the bacterial isochorismatase-like hydrolase SttH. Biosci. Biotechnol. Biochem. 73 (2009) 2494–2500. [DOI] [PMID: 19897889]
2.  Hamano, Y., Matsuura, N., Kitamura, M. and Takagi, H. A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific. J. Biol. Chem. 281 (2006) 16842–16848. [DOI] [PMID: 16641084]
[EC created 2011]

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