| EC |
3.5.2.19 |
| Accepted name: |
streptothricin hydrolase |
| Reaction: |
streptothricin-F + H2O = streptothricin-F acid |
| Other name(s): |
sttH (gene name) |
| Systematic name: |
streptothricin-F hydrolase |
| Comments: |
The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Maruyama, C. and Hamano, Y. The biological function of the bacterial isochorismatase-like hydrolase SttH. Biosci. Biotechnol. Biochem. 73 (2009) 2494–2500. [DOI] [PMID: 19897889] |
| 2. |
Hamano, Y., Matsuura, N., Kitamura, M. and Takagi, H. A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific. J. Biol. Chem. 281 (2006) 16842–16848. [DOI] [PMID: 16641084] |
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| [EC 3.5.2.19 created 2011] |
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