| EC |
3.5.2.16 |
| Accepted name: |
maleimide hydrolase |
| Reaction: |
maleimide + H2O = maleamic acid |
| Other name(s): |
imidase; cyclic imide hydrolase; cyclic-imide amidohydrolase (decyclicizing) [misprint]; cyclic-imide amidohydrolase (decyclizing) |
| Systematic name: |
cyclic-imide amidohydrolase (ring-opening) |
| Comments: |
Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC 3.5.2.2, dihydropyrimidinase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9030-74-4 |
| References: |
| 1. |
Ogawa, J., Soong, C.L., Honda, M. and Shimizu, S. Imidase, a new dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides. Eur. J. Biochem. 243 (1997) 322–327. [PMID: 9030755] |
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| [EC 3.5.2.16 created 2001] |
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