EC |
3.5.1.95 |
Accepted name: |
N-malonylurea hydrolase |
Reaction: |
3-oxo-3-ureidopropanoate + H2O = malonate + urea |
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For pyrimidine catabolism, click here |
Other name(s): |
ureidomalonase |
Systematic name: |
3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) |
Comments: |
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 368888-22-6 |
References: |
1. |
Soong, C.L., Ogawa, J. and Shimizu, S. Novel amidohydrolytic reactions in oxidative pyrimidine metabolism:
analysis of the barbiturase reaction and discovery of a novel enzyme,
ureidomalonase. Biochem. Biophys. Res. Commun. 286 (2001) 222–226. [DOI] [PMID: 11485332] |
2. |
Soong, C.L., Ogawa, J., Sakuradani, E. and Shimizu, S. Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative
pyrimidine metabolism. J. Biol. Chem. 277 (2002) 7051–7058. [DOI] [PMID: 11748240] |
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[EC 3.5.1.95 created 2006] |
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