| EC |
3.5.1.91 |
| Accepted name: |
N-substituted formamide deformylase |
| Reaction: |
N-benzylformamide + H2O = formate + benzylamine |
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For diagram of reaction, click here |
| Other name(s): |
NfdA |
| Systematic name: |
N-benzylformamide amidohydrolase |
| Comments: |
Zinc is a cofactor. While N-benzylformamide is the best substrate, the enzyme from Arthrobacter pascens can also act on the N-substituted formamides N-butylformamide, N-allylformamide, N-[2-(cyclohex-1-enyl)ethyl]formamide and N-(1-phenylethyl)formamide, but much more slowly. Amides of other acids do not act as substrates. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 115299-95-1 |
| References: |
| 1. |
Fukatsu, H., Hashimoto, Y., Goda, M., Higashibata, H. and Kobayashi, M. Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning. Proc. Natl. Acad. Sci. USA 101 (2004) 13726–13731. [DOI] [PMID: 15358859] |
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| [EC 3.5.1.91 created 2005] |
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