EC |
3.5.1.90 |
Accepted name: |
adenosylcobinamide hydrolase |
Reaction: |
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol |
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For diagram of cobinamide salvage pathways, click here |
Other name(s): |
CbiZ; AdoCbi amidohydrolase |
Systematic name: |
adenosylcobinamide amidohydrolase |
Comments: |
Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB). |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 905988-16-1 |
References: |
1. |
Woodson, J.D. and Escalante-Semerena, J.C. CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea. Proc. Natl. Acad. Sci. USA 101 (2004) 3591–3596. [DOI] [PMID: 14990804] |
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[EC 3.5.1.90 created 2004] |
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