ExplorEnz: EC 3.5.1.130

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3.5.1.130

Accepted name:

[amino group carrier protein]-lysine hydrolase

Reaction:

[amino group carrier protein]-C-terminal-γ-(L-lysyl)-L-glutamate + H₂O = [amino group carrier protein]-C-terminal-L-glutamate + L-lysine

Other name(s):

lysK (gene name)

Systematic name:

[amino group carrier protein]-C-terminal-γ-L-lysyl-L-glutamate amidohydrolase

Comments:

The enzyme participates in an L-lysine biosynthetic pathway in certain species of archaea and bacteria. In some organisms the enzyme also catalyses the activity of EC 3.5.1.132, [amino group carrier protein]-ornithine hydrolase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Horie, A., Tomita, T., Saiki, A., Kono, H., Taka, H., Mineki, R., Fujimura, T., Nishiyama, C., Kuzuyama, T. and Nishiyama, M. Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat. Chem. Biol. 5 (2009) 673–679. [DOI] [PMID: 19620981]
2.	Ouchi, T., Tomita, T., Horie, A., Yoshida, A., Takahashi, K., Nishida, H., Lassak, K., Taka, H., Mineki, R., Fujimura, T., Kosono, S., Nishiyama, C., Masui, R., Kuramitsu, S., Albers, S.V., Kuzuyama, T. and Nishiyama, M. Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus. Nat. Chem. Biol. 9 (2013) 277–283. [DOI] [PMID: 23434852]
3.	Yoshida, A., Tomita, T., Atomi, H., Kuzuyama, T. and Nishiyama, M. Lysine biosynthesis of Thermococcus kodakarensis with the capacity to function as an ornithine biosynthetic system. J. Biol. Chem. 291 (2016) 21630–21643. [DOI] [PMID: 27566549]
4.	Fujita, S., Cho, S.H., Yoshida, A., Hasebe, F., Tomita, T., Kuzuyama, T. and Nishiyama, M. Crystal structure of LysK, an enzyme catalyzing the last step of lysine biosynthesis in Thermus thermophilus, in complex with lysine: Insight into the mechanism for recognition of the amino-group carrier protein, LysW. Biochem. Biophys. Res. Commun. 491 (2017) 409–415. [DOI] [PMID: 28720495]

[EC 3.5.1.130 created 2019]