| EC |
3.5.1.123 |
| Accepted name: |
γ-glutamylanilide hydrolase |
| Reaction: |
N5-phenyl-L-glutamine + H2O = L-glutamate + aniline |
| Glossary: |
γ-glutamylanilide = N5-phenyl-L-glutamine |
| Other name(s): |
atdA2 (gene name) |
| Systematic name: |
N5-phenyl-L-glutamine amidohydrolase |
| Comments: |
The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that catalysed by EC 6.3.1.18, γ-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Takeo, M., Ohara, A., Sakae, S., Okamoto, Y., Kitamura, C., Kato, D. and Negoro, S. Function of a glutamine synthetase-like protein in bacterial aniline oxidation via γ-glutamylanilide. J. Bacteriol. 195 (2013) 4406–4414. [DOI] [PMID: 23893114] |
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| [EC 3.5.1.123 created 2016] |
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