| EC |
3.5.1.113 |
| Accepted name: |
2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase |
| Reaction: |
2′′′-acetyl-6′′′-deamino-6′′′-hydroxyneomycin C + H2O = 6′′′-deamino-6′′′-hydroxyneomycin C + acetate |
| Other name(s): |
neoL (gene name) |
| Systematic name: |
2′′′-acetyl-6′′′-hydroxyneomycin C hydrolase (acetate-forming) |
| Comments: |
Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 3.5.1.112, 2′-N-acetylparomamine deacetylase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. ChemBioChem 9 (2008) 865–869. [DOI] [PMID: 18311744] |
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| [EC 3.5.1.113 created 2012] |
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