The Enzyme Database

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Accepted name: lysostaphin
Reaction: Hydrolysis of the -Gly┼Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans
Other name(s): glycyl-glycine endopeptidase
Comments: A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9011-93-2
1.  Recsei, P.A., Gruss, A.D. and Novick, R.P. Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans. Proc. Natl. Acad. Sci. USA 84 (1987) 1127–1131. [DOI] [PMID: 3547405]
2.  Baba, T. and Schneewind, O. Target cell specificity of a bacteriocin molecule: A C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. EMBO J. 15 (1996) 4789–4797. [PMID: 8890152]
3.  Thumm, G. and Götz, F. Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus. Mol. Microbiol. 23 (1997) 1251–1265. [DOI] [PMID: 9106216]
[EC created 1997]

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