Accepted name: ruberlysin
Reaction: Cleavage of His10┼Leu, Ala14┼Leu, Tyr16┼Leu and Gly23┼Phe bonds in the B chain of insulin; His┼Pro, Pro┼Phe, and Trp┼Ser of angiotensin I; and Gly┼Phe of Met enkephalin
Other name(s): Crotalus ruber metalloendopeptidase II; hemorrhagic toxin II
Comments: A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family)
1.  Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom. Arch. Biochem. Biophys. 253 (1987) 108–121. [PMID: 2949699]
2.  Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- 2, isolated from the venom of Crotalus ruber ruber. J. Biochem. (Tokyo) 108 (1990) 711–719. [PMID: 2081731]
[EC created 1992]