Accepted name: adamalysin
Reaction: Cleavage of Phe1┼Val, His5┼Leu, His10┼Leu, Ala14┼Leu, Leu15┼Tyr, and Tyr16┼Leu of insulin B chain
Other name(s): Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II
Comments: From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)
1.  Kurecki, T., Laskowski, M., Sr. and Kress, L.F. Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human α1-proteinase inhibitor. J. Biol. Chem. 253 (1978) 8340–8345. [PMID: 309470]
[EC created 1992]