Accepted name: signal peptidase II
Reaction: Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa┼(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains
Other name(s): premurein-leader peptidase; prolipoprotein signal peptidase; leader peptidase II; premurein leader proteinase; leader peptidase II
Comments: An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8.
1.  Dev, I.K. and Ray, P.H. Signal peptidases and signal peptide hydrolases. J. Bioenerg. Biomembr. 22 (1990) 271–290. [PMID: 2202720]
2.  Zhao, X.-J. and Wu, H.C. Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene. FEBS Lett. 299 (1992) 80–84. [PMID: 1544479]
3.  Sankaran, K. and Wu, H.C. Bacterial prolipoprotein signal peptidase. Methods Enzymol. 248 (1995) 169–180. [PMID: 7674920]
[EC created 1984 as EC, transferred 1995 to EC]