The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: penicillopepsin
Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1′, but also cleaving Gly20┼Glu in the B chain of insulin. Clots milk, and activates trypsinogen
Other name(s): peptidase A; Penicillium janthinellum aspartic proteinase; acid protease A; Penicillium citrinum acid proteinase; Penicillium cyclopium acid proteinase; Penicillium expansum acid proteinase; Penicillium janthinellum acid proteinase; Penicillium expansum aspartic proteinase; Penicillium aspartic proteinase; Penicillium caseicolum aspartic proteinase; Penicillium roqueforti acid proteinase; Penicillium duponti aspartic proteinase; Penicillium citrinum aspartic proteinase
Comments: From the imperfect fungus Penicillium janthinellum. In peptidase family A1 (pepsin A family). Closely related enzymes have been isolated from P. roqueforti [2] and P. duponti [3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9074-08-2
1.  Mains, G., Takahashi, M., Sodek, J. and Hofmann, T. The specificity of penicillopepsin. Can. J. Biochem. 49 (1971) 1134–1149. [PMID: 4946839]
2.  Zevaco, C., Hermier, J. and Gripon, J.-C. Le système protéolytique de Penicillium roqueforti. II - Purification et propriétés de la protéase acide. Biochimie 55 (1973) 1353–1360. [PMID: 4790849]
3.  Emi, S., Myers, D.V. and Iacobucci, G.A. Purification and properties of the thermostable acid protease of Penicillium duponti. Biochemistry 15 (1976) 842–848. [PMID: 2287]
4.  Hofmann, T. Penicillopepsin. Methods Enzymol. 45 (1976) 434–450. [DOI] [PMID: 1012008]
5.  Hsu, I.-N., Delbaere, L.T.J., James, M.N.G. and Hofmann, T. Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin. Nature 266 (1977) 140–144. [PMID: 323722]
[EC created 1992 (EC created 1992 (EC created 1961 as EC, transferred 1972 to EC, modified 1981 [EC, EC, EC, EC, EC, EC and EC all created 1972 and incorporated 1978], part incorporated 1992)]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald