The Enzyme Database

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Accepted name: gingipain K
Reaction: Endopeptidase with strict specificity for lysyl bonds
Other name(s): Lys-gingipain; PrtP proteinase
Comments: Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 159745-69-4
1.  Pike, R., McGraw, W., Potempa, J. and Travis, J. Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins. J. Biol. Chem. 269 (1994) 406–411. [PMID: 8276827]
2.  Curtis, M.A., Aduse, O.J., Rangarajan, M., Gallagher, A., Sterne, J.A., Reid, C.R., Evans, H.E. and Samuelsson, B. Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor 2. Infect. Immun. 70 (2002) 6968–6975. [DOI] [PMID: 12438376]
[EC created 2003]

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