| EC |
3.4.22.42 |
| Accepted name: |
cathepsin O |
| Reaction: |
The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec |
| Comments: |
Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32 |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, CAS registry number: 162032-86-2 |
| References: |
| 1. |
Santamaría, I., Pendás, A.M. and López-Otín, C. Genomic structure and chromosomal localization of a human cathepsin O gene (CTSO). Genomics 53 (1998) 231–234. [DOI] [PMID: 9790772] |
| 2. |
Velasco, G., Ferrando, A.A., Puente, X.S., Sanchez, L.M. and López-Otín, C. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. J. Biol. Chem. 269 (1994) 27136–27142. [PMID: 7929457] |
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| [EC 3.4.22.42 created 2000] |
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