The Enzyme Database

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Accepted name: histolysain
Reaction: Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg┼ in small molecule substrates including Z-Arg-Arg┼NHMec
Other name(s): histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase
Comments: From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family)
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, CAS registry number: 92228-52-9
1.  Lushbaugh, W.B., Hofbauer, A.F. and Pittman, F.E. Entamoeba histolytica: purification of cathepsin B. Exp. Parasitol. 59 (1985) 328–336. [PMID: 2860002]
2.  Luaces, A.L. and Barrett, A.J. Affinity purification and biochemical characterization of histolysin: the major cysteine proteinase of Entamoeba histolytica. Biochem. J. 250 (1988) 903–909. [PMID: 2898937]
[EC created 1992]

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