The Enzyme Database

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Accepted name: thrombin
Reaction: Selective cleavage of Arg┼Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Other name(s): fibrinogenase; thrombase; thrombofort; topical; thrombin-C; tropostasin; activated blood-coagulation factor II; blood-coagulation factor IIa; factor IIa; E thrombin; β-thrombin; γ-thrombin
Comments: Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9002-04-4
1.  Baughman, D.J. Thrombin assay. Methods Enzymol. 19 (1970) 145–157.
2.  Magnusson, S. Bovine prothrombin and thrombin. Methods Enzymol. 19 (1970) 157–184.
3.  Miller, K.D. Horse prothrombin. Methods Enzymol. 19 (1970) 140–145.
4.  Lundblad, R.L., Kingdon, H.S. and Mann, K.G. Thrombin. Methods Enzymol. 45 (1976) 156–176. [DOI] [PMID: 1011989]
5.  Mann, K.G. Prothrombin. Methods Enzymol. 45 (1976) 123–156. [DOI] [PMID: 1011988]
6.  Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade. Adv. Enzymol. 48 (1979) 277–318. [PMID: 367103]
7.  Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644–650. [PMID: 6370301]
8.  MacGillivray, R.T.A. and Davie, E.W. Characterization of bovine prothrombin mRNA and its translation product. Biochemistry 23 (1984) 1626–1634. [PMID: 6326805]
[EC created 1961 as EC, transferred 1972 to EC]

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