| EC |
3.4.14.10 |
| Accepted name: |
tripeptidyl-peptidase II |
| Reaction: |
Release of an N-terminal tripeptide from a polypeptide |
| Other name(s): |
tripeptidyl aminopeptidase; tripeptidyl peptidase; tripeptidyl aminopeptidase II; tripeptidyl peptidase II; TPP |
| Comments: |
A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8 |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 101149-94-4 |
| References: |
| 1. |
Bålöw, R.M., Ragnarsson, U. and Zetterqvist, Ö. Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver. J. Biol. Chem. 258 (1983) 11622–11628. [PMID: 6352701] |
| 2. |
Bålöw, R.M., Tomkinson, B., Ragnarsson, U. and Zetterqvist, Ö. Purification, substrate specificity, and classification of tripeptidyl peptidase II. J. Biol. Chem. 261 (1986) 2409–2417. [PMID: 3511062] |
| 3. |
Tomkinson, B. and Zetterqvist, Ö. Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin. Biochem. J. 267 (1990) 149–154. [PMID: 1691635] |
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| [EC 3.4.14.10 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)] |
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