| EC |
3.3.2.15 |
| Accepted name: |
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase |
| Reaction: |
(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate |
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For diagram of enediyne antitumour antibiotic biosynthesis and pyocyanin biosynthesis, click here |
| Glossary: |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate = trans-2,3-dihydro-3-hydroxyanthranilate |
| Other name(s): |
isochorismatase (ambiguous); phzD (gene name) |
| Systematic name: |
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase |
| Comments: |
Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Mavrodi, D.V., Bonsall, R.F., Delaney, S.M., Soule, M.J., Phillips, G. and Thomashow, L.S. Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. J. Bacteriol. 183 (2001) 6454–6465. [DOI] [PMID: 11591691] |
| 2. |
Parsons, J.F., Calabrese, K., Eisenstein, E. and Ladner, J.E. Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway. Biochemistry 42 (2003) 5684–5693. [DOI] [PMID: 12741825] |
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| [EC 3.3.2.15 created 2016] |
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