| EC |
3.3.2.14 |
| Accepted name: |
2,4-dinitroanisole O-demethylase |
| Reaction: |
2,4-dinitroanisole + H2O = methanol + 2,4-dinitrophenol |
| Glossary: |
2,4-dinitroanisole = 1-methoxy-2,4-dinitrobenzene |
| Other name(s): |
2,4-dinitroanisole ether hydrolase; dnhA (gene name); dnhB (gene name); DNAN demethylase |
| Systematic name: |
2,4-dinitroanisole methanol hydrolase |
| Comments: |
The enzyme, characterized from the bacterium Nocardioides sp. JS1661, is involved in the degradation of 2,4-dinitroanisole. Unlike other known O-demethylases, such as EC 1.14.99.15, 4-methoxybenzoate monooxygenase (O-demethylating), or EC 1.14.11.32, codeine 3-O-demethylase, it does not require oxygen or electron donors, and produces methanol rather than formaldehyde. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Fida, T.T., Palamuru, S., Pandey, G. and Spain, J.C. Aerobic biodegradation of 2,4-dinitroanisole by Nocardioides sp. strain JS1661. Appl. Environ. Microbiol. 80 (2014) 7725–7731. [DOI] [PMID: 25281383] |
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| [EC 3.3.2.14 created 2015] |
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