The Enzyme Database

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Accepted name: glycosylceramidase
Reaction: a glycosyl-N-acylsphingosine + H2O = a ceramide + a sugar
For diagram of glycolipid biosynthesis, click here
Glossary: a ceramide = an N-acylsphingosine
Other name(s): phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin β-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase
Systematic name: glycosyl-N-acylsphingosine glycohydrolase
Comments: Broad specificity [cf. EC (glucosylceramidase) and EC (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC lactase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-10-7
1.  Leese, H.J. and Semenza, G. On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. J. Biol. Chem. 248 (1973) 8170–8173. [PMID: 4752949]
2.  Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase. Eur. J. Clin. Invest. 2 (1972) 326–331. [DOI] [PMID: 5082068]
3.  Malathi, P. and Crane, R.K. Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane. Biochim. Biophys. Acta 173 (1969) 245–256. [DOI] [PMID: 5774775]
[EC created 1972, modified 1976]

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