The Enzyme Database

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Accepted name: endo-(1→4)-fucoidanase
Reaction: endohydrolysis of (1→4)-α-L-fucoside linkages in fucan
Other name(s): α-L-fucosidase (incorrect); poly(1,4-α-L-fucoside-2/3-sulfate) glycanohydrolase
Systematic name: poly[(1→4)-α-L-fucoside-2/3-sulfate] glycanohydrolase
Comments: The enzyme specifically hydrolyses (1→4)-α-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1→3)-linked or alternating (1→3)- and (1→4)-linked α-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the α-L-fucopyranosyl residues may occur at positions 2 and 3. The enzyme degrades fucan to sulfated α-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Thanassi, N.M. and Nakada, H.I. Enzymic degradation of fucoidan by enzymes from the hepatopancreas of abalone, Halotus species. Arch. Biochem. Biophys. 118 (1967) 172–177.
2.  Berteau, O. and Mulloy, B. Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13 (2003) 29R–40R. [PMID: 12626402]
3.  Descamps, V., Colin, S., Lahaye, M., Jam, M., Richard, C., Potin, P., Barbeyron, T., Yvin, J.C. and Kloareg, B. Isolation and culture of a marine bacterium degrading the sulfated fucans from marine brown algae. Mar Biotechnol (NY) 8 (2006) 27–39. [PMID: 16222488]
4.  Kim, W.J., Kim, S.M., Lee, Y.H., Kim, H.G., Kim, H.K., Moon, S.H., Suh, H.H., Jang, K.H. and Park, Y.I. Isolation and characterization of marine bacterial strain degrading fucoidan from Korean Undaria pinnatifida Sporophylls. J. Microbiol. Biotechnol. 18 (2008) 616–623. [PMID: 18467852]
5.  Silchenko, A.S., Kusaykin, M.I., Kurilenko, V.V., Zakharenko, A.M., Isakov, V.V., Zaporozhets, T.S., Gazha, A.K. and Zvyagintseva, T.N. Hydrolysis of fucoidan by fucoidanase isolated from the marine bacterium, Formosa algae. Mar. Drugs 11 (2013) 2413–2430. [PMID: 23852092]
6.  Silchenko, A.S., Kusaykin, M.I., Zakharenko, A.M., Menshova, R.V., Khanh, H.H.N., Dmitrenok, P.S., Isakov, V.V., Zvyagintseva, T.N. Endo-1,4-fucoidanase from vietnamese marine mollusk Lambis sp. which producing sulphated fucooligosaccharides. J. Mol. Catal. B 102 (2014) 154–160.
7.  Silchenko, A.S., Ustyuzhanina, N.E., Kusaykin, M.I., Krylov, V.B., Shashkov, A.S., Dmitrenok, A.S., Usoltseva, R.V., Zueva, A.O., Nifantiev, N.E. and Zvyagintseva, T.N. Expression and biochemical characterization and substrate specificity of the fucoidanase from Formosa algae. Glycobiology 27 (2017) 254–263. [PMID: 28031251]
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