ExplorEnz: EC 3.2.1.208

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3.2.1.208

Accepted name:

glucosylglycerate hydrolase

Reaction:

2-O-(α-D-glucopyranosyl)-D-glycerate + H₂O = D-glucopyranose + D-glycerate

Other name(s):

GG hydrolase; GgH

Systematic name:

2-O-(α-D-glucopyranosyl)-D-glycerate D-glucohydrolase

Comments:

The enzyme has been isolated from nontuberculous mycobacteria (e.g. Mycobacterium hassiacum), which accumulate 2-O-(α-D-glucopyranosyl)-D-glycerate during growth under nitrogen deprivation.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Alarico, S., Costa, M., Sousa, M.S., Maranha, A., Lourenco, E.C., Faria, T.Q., Ventura, M.R. and Empadinhas, N. Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate. Sci. Rep. 4:6766 (2014). [PMID: 25341489]
2.	Cereija, T.B., Alarico, S., Empadinhas, N. and Pereira, P.JB. Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase. Acta Crystallogr. F Struct. Biol. Commun. 73 (2017) 536–540. [PMID: 28876234]

[EC 3.2.1.208 created 2018]