The Enzyme Database

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Accepted name: endo-α-sialidase
Reaction: Endohydrolysis of (2→8)-α-sialosyl linkages in oligo- or poly(sialic) acids
Other name(s): endo-N-acylneuraminidase; endoneuraminidase; endo-N-acetylneuraminidase; poly(α-2,8-sialosyl) endo-N-acetylneuraminidase; poly(α-2,8-sialoside) α-2,8-sialosylhydrolase; endosialidase; endo-N
Systematic name: polysialoside (2→8)-α-sialosylhydrolase
Comments: Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetylated substrates. An exo-α-sialidase activity is listed as EC exo-α-sialidase. See also EC anhydrosialidase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 91195-87-8
1.  Finne, J., Mäkelä, P.H. Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid. J. Biol. Chem. 260 (1985) 1265–1270. [PMID: 3968060]
2.  Hallenbeck, P.C., Vimr, E.R., Yu, F., Bassler, B. and Troy, F.A. Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-α-2,8-sialosyl carbohydrate units. J. Biol. Chem. 262 (1987) 3553–3561. [PMID: 3546309]
3.  Kitakima, K., Inoue, S., Inoue, Y. and Troy, F.A. Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies. J. Biol. Chem. 263 (1988) 18269–18276. [PMID: 3142874]
4.  Kwiatkowski, B., Boscheck, B., Thicle, H. and Stirm, S. Endo-N-acetylneuraminidase associated with bacteriophage particles. J. Virol. 43 (1982) 697–704. [PMID: 7109038]
5.  Pelkonen, S., Pelkonen, J. and Finne, J. Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins. J. Virol. 65 (1989) 4409–4416. [PMID: 2778882]
6.  Tombinson, S. and Taylor, P.W. Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide. J. Virol. 55 (1985) 374–378. [PMID: 3894684]
7.  Cabezas, J.A. Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase. Biochem. J. 278 (1991) 311–312. [PMID: 1883340]
[EC created 1990, modified 1999]

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