| EC |
3.13.1.9 |
| Accepted name: |
S-inosyl-L-homocysteine hydrolase |
| Reaction: |
S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine |
| Other name(s): |
SIHH |
| Systematic name: |
S-inosyl-L-homocysteine hydrolase (inosine-forming) |
| Comments: |
The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Miller, D., Xu, H. and White, R.H. S-Inosyl-L-homocysteine hydrolase, a novel enzyme involved in S-adenosyl-L-methionine recycling. J. Bacteriol. 197 (2015) 2284–2291. [DOI] [PMID: 25917907] |
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| [EC 3.13.1.9 created 2020] |
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