ExplorEnz: EC 3.13.1.3

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3.13.1.3

Accepted name:

2′-hydroxybiphenyl-2-sulfinate desulfinase

Reaction:

2′-hydroxybiphenyl-2-sulfinate + H₂O = 2-hydroxybiphenyl + sulfite

For diagram of reaction, click here

Other name(s):

gene dszB-encoded hydrolase; 2-(2-hydroxyphenyl) benzenesulfinate:H₂O hydrolase; DszB; HBPSi desulfinase; 2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase; HPBS desulfinase; 2-(2-hydroxyphenyl)benzenesulfinate hydrolase; 2-(2′-hydroxyphenyl)benzenesulfinate desulfinase; 2-(2-hydroxyphenyl)benzenesulfinate desulfinase

Systematic name:

2′-hydroxybiphenyl-2-sulfinate sulfohydrolase

Comments:

The enzyme from Rhodococcus sp. strain IGTS8 is encoded by the plasmid-encoded dibenzothiophene-desulfurization (dsz) operon. The enzyme has a narrow substrate specificity with biphenyl-2-sulfinate being the only other substrate known to date [2].

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 198154-06-2

References:

1.	Oldfield, C., Pogrebinsky, O., Simmonds, J., Ölson, E.S. and Kulpa, C.F. Elucidation of the metabolic pathway for dibenzothiophene desulfurization by Rhodococcus sp. strain IGTS8 (ATCC 53968). Microbiology 143 (1997) 2961–2973. [DOI] [PMID: 9308179]
2.	Nakayama, N., Matsubara, T., Ohshiro, T., Moroto, Y., Kawata, Y., Koizumi, K., Hirakawa, Y., Suzuki, M., Maruhashi, K., Izumi, Y. and Kurane, R. A novel enzyme, 2′-hydroxybiphenyl-2-sulfinate desulfinase (DszB), from a dibenzothiophene-desulfurizing bacterium Rhodococcus erythropolis KA2-5-1: gene overexpression and enzyme characterization. Biochim. Biophys. Acta 1598 (2002) 122–130. [DOI] [PMID: 12147352]
3.	Watkins, L.M., Rodriguez, R., Schneider, D., Broderick, R., Cruz, M., Chambers, R., Ruckman, E., Cody, M. and Mrachko, G.T. Purification and characterization of the aromatic desulfinase, 2-(2′-hydroxyphenyl)benzenesulfinate desulfinase. Arch. Biochem. Biophys. 415 (2003) 14–23. [DOI] [PMID: 12801508]

[EC 3.13.1.3 created 2000 as EC 3.1.2.24, transferred 2005 to EC 3.13.1.3]