| EC |
3.1.6.4 |
| Accepted name: |
N-acetylgalactosamine-6-sulfatase |
| Reaction: |
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate |
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For diagram of the later stages of chondroitin biosynthesis, click here |
| Other name(s): |
chondroitin sulfatase; chondroitinase; galactose-6-sulfate sulfatase; acetylgalactosamine 6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine 6-sulfatase |
| Systematic name: |
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9025-60-9 |
| References: |
| 1. |
Epstein, E.H. and Leventhal, M.E. Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis. J. Clin. Invest. 67 (1981) 1257–1262. [DOI] [PMID: 6939689] |
| 2. |
Glössl, J. and Kresse, H. Impaired degradation of keratan sulphate by Morquio A fibroblasts. Biochem. J. 203 (1982) 335–338. [PMID: 6213226] |
| 3. |
Lim, C.T. and Horwitz, A.L. Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase. Biochim. Biophys. Acta 657 (1981) 344–355. [DOI] [PMID: 7213753] |
| 4. |
Sørensen, S.H., Norén, O., Sjöström, H. and Danielsen, E.M. Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity. Eur. J. Biochem. 126 (1982) 559–568. [DOI] [PMID: 6814909] |
| 5. |
Yutaka, T., Okada, S., Kato, T., Inui, K. and Yabuchi, H. Galactose 6-sulfate sulfatase activity in Morquio syndrome. Clin. Chim. Acta 122 (1982) 169–180. [DOI] [PMID: 6809361] |
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| [EC 3.1.6.4 created 1961] |
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