The Enzyme Database

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Accepted name: RNA 2′,3′-cyclic 3′-phosphodiesterase
Reaction: (ribonucleotide)n-2′,3′-cyclic phosphate + H2O = (ribonucleotide)n-2′-phosphate
Other name(s): thpR (gene name); ligT (gene name)
Systematic name: (ribonucleotide)n-2′,3′-cyclic phosphate 3′-nucleotidohydrolase
Comments: The enzyme hydrolyses RNA 2′,3′-cyclic phosphodiester to an RNA 2′-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2′,3′-cyclic phosphate to tRNA with 5′-hydroxyl termini, forming a 2′-5′ phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Kanai, A., Sato, A., Fukuda, Y., Okada, K., Matsuda, T., Sakamoto, T., Muto, Y., Yokoyama, S., Kawai, G. and Tomita, M. Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus. RNA 15 (2009) 420–431. [DOI] [PMID: 19155324]
2.  Remus, B.S., Jacewicz, A. and Shuman, S. Structure and mechanism of E. coli RNA 2′,3′-cyclic phosphodiesterase. RNA 20 (2014) 1697–1705. [DOI] [PMID: 25239919]
[EC created 2017]

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