ExplorEnz: EC 3.1.4.57

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3.1.4.57

Accepted name:

phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase

Reaction:

(1) 5-phospho-α-D-ribose 1,2-cyclic phosphate + H₂O = D-ribofuranose 2,5-bisphosphate
(2) D-ribofuranose 2,5-bisphosphate + H₂O = D-ribofuranose 5-phosphate + phosphate

Other name(s):

cyclic phosphate dihydrolase; phnPP (gene name)

Systematic name:

5-phospho-α-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase

Comments:

The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Ghodge, S.V., Cummings, J.A., Williams, H.J. and Raushel, F.M. Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus. J. Am. Chem. Soc. 135 (2013) 16360–16363. [DOI] [PMID: 24147537]

[EC 3.1.4.57 created 2014]