The Enzyme Database

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Accepted name: phosphodiesterase I
Reaction: Hydrolytically removes 5′-nucleotides successively from the 3′-hydroxy termini of 3′-hydroxy-terminated oligonucleotides
Other name(s): 5′-exonuclease; 5′-phosphodiesterase; 5′-nucleotide phosphodiesterase; oligonucleate 5′-nucleotidohydrolase; 5′ nucleotide phosphodiesterase/alkaline phosphodiesterase I; 5′-NPDase; 5′-PDase; 5′-PDE; 5’NPDE; alkaline phosphodiesterase; nucleotide pyrophosphatase/phosphodiesterase I; orthophosphoric diester phosphohydrolase; PDE I; phosphodiesterase (ambiguous); exonuclease I
Systematic name: oligonucleotide 5′-nucleotidohydrolase
Comments: Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3′-phosphate terminus on the substrate inhibits hydrolysis.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9025-82-5
1.  Khorana, G.H. Phosphodiesterases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 5, Academic Press, New York, 1961, pp. 79–94.
[EC created 1961]

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