| EC |
3.1.3.48 |
| Accepted name: |
protein-tyrosine-phosphatase |
| Reaction: |
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate |
| Other name(s): |
phosphotyrosine phosphatase; phosphoprotein phosphatase (phosphotyrosine); phosphotyrosine histone phosphatase; protein phosphotyrosine phosphatase; tyrosylprotein phosphatase; phosphotyrosine protein phosphatase; phosphotyrosylprotein phosphatase; tyrosine O-phosphate phosphatase; PPT-phosphatase; PTPase; [phosphotyrosine]protein phosphatase; PTP-phosphatase |
| Systematic name: |
protein-tyrosine-phosphate phosphohydrolase |
| Comments: |
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 79747-53-8 |
| References: |
| 1. |
Foulkes, J.G., Howard, R.F. and Ziemiecki, A. Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine. FEBS Lett. 130 (1981) 197–200. [DOI] [PMID: 6169552] |
| 2. |
Gallis, B., Bornstein, P. and Brautigan, D.L. Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells. Proc. Natl. Acad. Sci. USA 78 (1981) 6689–6693. [DOI] [PMID: 6273884] |
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| [EC 3.1.3.48 created 1984] |
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